Inhibition of cartilage degradation in rat collagen-induced arthritis but not adjuvant arthritis by the neutrophil elastase inhibitor MDL 101,146

被引：13

作者：

Janusz, MJ ^{[1
]}

Durham, SL ^{[1
]}

机构：

[1] Hoechst Mar Roussel Pharmaceut, Cincinnati, OH 45215 USA

来源：

INFLAMMATION RESEARCH | 1997年 / 46卷 / 12期

关键词：

neutrophil elastase; adjuvant arthritis; collagen arthritis; MDL 101,146; cartilage degradation;

D O I：

10.1007/s000110050233

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objective and Design: The neutrophil elastase inhibitor MDL 101,146 was examined for its anti-arthritic effect and to determine the role of neutrophil elastase in collagen-induced arthritis and adjuvant arthritis. Material: The collagen-induced arthritis model was performed in female DA rats immunized on day 0 and 7 with chick type II collagen in Freund's incomplete adjuvant. Adjuvant arthritis was induced in female Lewis rats by an intradermal injection of heat-killed Mycobacterium tuberculosis H37RA. Methods: The clinical signs of arthritis were assessed, joint swelling was measured using calipers and bone degradation, new bone proliferation, pannus formation and cartilage degradation were evaluated histologically. Results: MDL 101,146 administered orally inhibited the severity of collagen-induced arthritis as measured by a reduction in clinical score and joint swelling. Histological evaluation demonstrated a bone and cartilage sparing effect of MDL 101,146 in the tibio-tarsal joint of animals with collagen-induced arthritis. Conclusions: These results suggest that destruction of the joint in collagen-induced arthritis is at least partially due to neutrophil elastase.

引用

页码：503 / 508

页数：6

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