Melanocortins and body weight: a tale of two receptors

被引：51

作者：

Cummings, DE ^{[1
]}

Schwartz, MW

机构：

[1] Univ Washington, VA Puget Sound Hlth Care Syst, Dept Med, Seattle, WA 98108 USA

[2] Harborview Med Ctr, Seattle, WA 98108 USA

来源：

NATURE GENETICS | 2000年 / 26卷 / 01期

关键词：

D O I：

10.1038/79223

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The phenotypes of mice lacking melanocortin-3 (Mcr3) and melanocortin4 receptors (Mc4r) demonstrate that these isoforms reduce body weight through distinct and complementary mechanisms. Mc4r regulates food intake and possibly energy expenditure, whereas Mc3r influences feed efficiency and the partitioning of fuel stores into fat.

引用

页码：8 / 9

页数：2

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