Mechanism of albuminuria associated with cardiovascular disease and kidney disease

被引：31

作者：

Russo, LM

Comper, WD

Osicka, TM

机构：

[1] AusAm Biotechnol Inc, New York, NY 10022 USA

[2] Massachusetts Gen Hosp, Dept Med, Renal Unit, Program Membrane Biol, Charlestown, MA USA

[3] Harvard Univ, Sch Med, Charlestown, MA USA

[4] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3168, Australia

来源：

KIDNEY INTERNATIONAL | 2004年 / 66卷

关键词：

lysosome; albumin degradation; albumm-derived fragments;

D O I：

10.1111/j.1523-1755.2004.09218.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The major underlying factors associated with tissue damage and fibrosis in cardiovascular and kidney disease are the up-regulation and action of growth factors such as transforming growth factor-beta (TGF-Pbeta) and cytokines produced in response to changes in systemic factors, particularly blood pressure or hyperalycemia. This study identifies the relationship of elevated levels of TGF-beta to increased levels of intact albumin in the urine (micro- and macroalbuminuria). This mechanism may be directly linked to the effect of TGF-beta on albumin uptake and the lysosomal breakdown of filtered albumin by proximal tubular cells prior to excretion.

引用

页码：S67 / S68

页数：2

共 6 条

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