Physical activity, growth, and inflammatory mediators in BMI-Matched female adolescents

被引:56
作者
Ischander, Mariam
Zaldivar, Frank, Jr.
Eliakim, Alon
Nussbaum, Eliezer
Dunton, Genevieve
Leu, Szu-Yun
Cooper, Dan Michael
Schneider, Margaret
机构
[1] Univ Calif Irvine, Pediat Exercise Res Ctr, Irvine, CA USA
[2] Millers Childrens Hosp, Long Beach, CA USA
[3] Tel Aviv Univ, Sackler Sch Med, Meir Med Ctr, Tel Aviv, Israel
[4] Univ So Calif, Dept Prevent Med, Los Angeles, CA USA
关键词
fitness; inflammation; adolescence; bone mineralization; body composition; growth mediators;
D O I
10.1249/mss.0b013e318053e7a2
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
Purpose: Physical inactivity is deleterious to health, but it has been difficult to determine the extent to which these effects are attributable to abnormal body composition or to factors related to physical activity alone. To begin to gauge independent effects of physical activity on health risk, we matched by BMI two groups of normal-weight adolescent females, one physically active (all participants in high school sports), and one sedentary. Methods: Thirty-seven sedentary and 37 physically active adolescent females (mean 15.5 yr) were matched for age and BMI percentile (mean = 58.8). Comparisons included fitness, body composition and bone mineralization (by DEXA), circulating inflammatory cytokines, growth factors, bone-turnover markers, leptin, and adiponectin. Results: Compared with the normal-weight sedentary girls, active girls had significantly (P < 0.05) higher fitness level (peak VO2 35.5 +/- 5.2 vs 24.4 +/- 4.1 mL center dot kg(-1)center dot min(-1)), lean body mass (43.2 +/- 4.4 vs 38.7 +/- 3.6 kg), bone mineralization (spinal BMD z-scores 0.04 +/- 0.88 vs -0.41 +/- 0.85), and lower percent body fat (25.4 +/- 04.6 vs 29.7 +/- 03.7%). Additionally, active girls had lower inflammatory cytokines levels (e.g., TNF-alpha 1.7 +/- 1.3 vs 2.6 +/- 2.2 pg center dot mL(-1)), and leptin (17.4 +/- 11.2 vs 24.7 +/- 14.7 ng center dot mL(-1)), and higher bone-turnover markers (e.g. osteocalcin 12.6 +/- 7.6 vs 7.8 +/- 3.0 U center dot L-1), IGFBP-3 (6416 +/- 21280 vs 4247 +/- 1082 ng center dot rnL(-1)), and adiponectin levels (11919 +/- 3935 vs 9305 +/- 2843 ng center dot mL(-1)). Conclusion: The normal-weight, physically active group was fitter and had greater lean body mass, stronger bones, and lower levels of inflammatory markers than did the normal-weight, sedentary group. in adolescent girls, the choice of a lifestyle involving high school sports is characterized by a circulating mediator and body composition pattern that, if sustained, is associated with generally lower long-term risk of cardiovascular disease and osteoporosis.
引用
收藏
页码:1131 / 1138
页数:8
相关论文
共 31 条
  • [1] Compendium of Physical Activities: an update of activity codes and MET intensities
    Ainsworth, BE
    Haskell, WL
    Whitt, MC
    Irwin, ML
    Swartz, AM
    Strath, SJ
    O'Brien, WL
    Bassett, DR
    Schmitz, KH
    Emplaincourt, PO
    Jacobs, DR
    Leon, AS
    [J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2000, 32 (09) : S498 - S516
  • [2] Anderson SJ, 2000, PEDIATRICS, V105, P1156
  • [3] Prevalence and cardiovascular disease correlates of low cardiorespiratory fitness in adolescents and adults
    Carnethon, MR
    Gulati, M
    Greenland, P
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (23): : 2981 - 2988
  • [4] Review: developmental origins of osteoporotic fracture
    Cooper, C
    Westlake, S
    Harvey, N
    Javaid, K
    Dennison, E
    Hanson, M
    [J]. OSTEOPOROSIS INTERNATIONAL, 2006, 17 (03) : 337 - 347
  • [5] Exercise, stress, and inflammation in the growing child: from the bench to the playground
    Cooper, DM
    Nemet, D
    Galassetti, P
    [J]. CURRENT OPINION IN PEDIATRICS, 2004, 16 (03) : 286 - 292
  • [6] AEROBIC PARAMETERS OF EXERCISE AS A FUNCTION OF BODY SIZE DURING GROWTH IN CHILDREN
    COOPER, DM
    WEILERRAVELL, D
    WHIPP, BJ
    WASSERMAN, K
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1984, 56 (03) : 628 - 634
  • [7] Physical activity, fitness, and physical self-concept in adolescent females
    Dunton, Genevieve Fridlund
    Schneider, Margaret
    Graham, Dan J.
    Cooper, Dan M.
    [J]. PEDIATRIC EXERCISE SCIENCE, 2006, 18 (02) : 240 - 251
  • [8] Physical fitness, endurance training, and the growth hormone insulin-like growth factor I system in adolescent females
    Eliakim, A
    Brasel, JA
    Mohan, S
    Barstow, TJ
    Berman, N
    Cooper, DM
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (11) : 3986 - 3992
  • [9] Relationship between caloric intake, body composition, and physical activity to leptin, thyroid hormones, and-cortisol in adolescents
    Hackney, AC
    McMurray, RG
    Judelson, DA
    Harrell, JS
    [J]. JAPANESE JOURNAL OF PHYSIOLOGY, 2003, 53 (06) : 475 - 479
  • [10] Fat as an endocrine organ: Relationship to the metabolic syndrome
    Hutley, L
    Prins, JB
    [J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2005, 330 (06) : 280 - 289