Isolation and Characterization of a New Ginsenoside from the Fresh Root of Panax Ginseng

被引：46

作者：

Ruan, Chang-Chun ^{[1
,2
]}

Liu, Zhi ^{[2
]}

Li, Xiang ^{[3
,4
]}

Liu, Xia ^{[1
]}

Wang, Li-Juan ^{[1
]}

Pan, Hong-Yu ^{[4
]}

Zheng, Yi-Nan ^{[1
]}

Sun, Guang-Zhi ^{[2
]}

Zhang, Yan-Sheng ^{[5
]}

Zhang, Lian-Xue ^{[1
]}

机构：

[1] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China

[2] Jilin Agr Univ, Inst Agr Modernizat, Changchun 130118, Peoples R China

[3] Agr & Agri Food Canada, Saskatoon Res Ctr, Saskatoon, SK S7N 0X2, Canada

[4] Jilin Univ, Coll Plant Sci, Changchun 130062, Peoples R China

[5] Chinese Acad Sci, Wuhan Bot Garden, Wuhan 430074, Peoples R China

来源：

MOLECULES | 2010年 / 15卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Panax ginseng; ginsenoside; malonyl-ginsenoside Ra-3; SAPONINS; LEAVES;

D O I：

10.3390/molecules15042319

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new saponin, malonylginsenoside Ra-3, was isolated from the fresh root of Panax ginseng, along with four known ginsenosides. The new compound was identified as (20S)-protopanaxadiol-3-O-(6-O-malonyl-beta-D-glucopyranosyl(1 -> 2)-beta-D-glucopyranoside -20-O-beta-D-xylopyranosyl(1 -> 3)-beta-D-glucopyranosyl(1 -> 6)-beta-D-glucopyranoside on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis.

引用

页码：2319 / 2325

页数：7

共 15 条

[1] Saponins in tumor therapy [J].

Bachran, Christopher ;

Bachran, Silke ;

Sutherland, Mark ;

Bachran, Diana ;

Fuchs, Hendrik .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2008, 8 (06) :575-584

[2]

KITAGAWA I, 1983, CHEM PHARM BULL, V31, P3353

[3] Isolation, synthesis and structures of cytotoxic ginsenoside derivatives [J].

Lei, Jun ;

Li, Xiang ;

Gong, Xiao-Jie ;

Zheng, Yi-Nan .

MOLECULES, 2007, 12 (09) :2140-2150

[4]

LI XG, 2000, DRUG DISCOVERY TRADI, P97

[5] Rubiacordone A: A New Anthraquinone Glycoside from the Roots of Rubia cordifolia [J].

Li, Xiang ;

Liu, Zhi ;

Chen, Yun ;

Wang, Li-Juan ;

Zheng, Yi-Nan ;

Sun, Guang-Zhi ;

Ruan, Chang-Chun .

MOLECULES, 2009, 14 (01) :566-572

[6] Isolation and characterization of phenolic compounds from the leaves of Salix matsudana [J].

Li, Xiang ;

Liu, Zhi ;

Zhang, Xin-feng ;

Wang, Li-juan ;

Zheng, Yi-nan ;

Yuan, Chang-chun ;

Sun, Guang-zhi .

MOLECULES, 2008, 13 (08) :1530-1537

[7] Hypoglycemic Effects of Malonyl-ginsenosides Extracted from Roots of Panax ginseng on Streptozotocin-induced Diabetic Mice [J].

Liu, Zhi ;

Wang, Li-Juan ;

Li, Xiang ;

Hu, Jiang-Ning ;

Chen, Yun ;

Ruan, Chang-Chun ;

Sun, Guang-Zhi .

PHYTOTHERAPY RESEARCH, 2009, 23 (10) :1426-1430

[8]

MATSUURA H, 1984, CHEM PHARM BULL, V32, P1188

[9] Biotransformation of Ginsenoside Rf to Rh1 by Recombinant β-Glucosidase [J].

Ruan, Chang-Chun ;

Zhang, Hao ;

Zhang, Lian-Xue ;

Liu, Zhi ;

Sun, Guang-Zhi ;

Lei, Jun ;

Qin, Yu-Xia ;

Zheng, Yi-Nan ;

Li, Xiang ;

Pan, Hong-Yu .

MOLECULES, 2009, 14 (06) :2043-2048

[10]

Sun GZ, 2005, CHINESE J ANAL CHEM, V33, P1783

← 1 2 →