Molecular mechanisms utilized by alternative c-kit gene products in the control of spermatogonial proliferation and sperm-mediated egg activation
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作者:
Rossi, P
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Univ Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, Italy
Rossi, P
[1
]
Dolci, S
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Univ Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, Italy
Dolci, S
[1
]
Sette, C
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Univ Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, Italy
Sette, C
[1
]
Geremia, R
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Univ Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, ItalyUniv Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, Italy
Geremia, R
[1
]
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[1] Univ Roma Tor Vergata, Dipartimento Sanita Pubbl & Biol Cellulare, Sez Anat, I-00133 Rome, Italy
The c-kit proto-oncogene plays a dual role in the control of male fertility in mice through two alternative gene products: (1) c-kit [the transmembrane tyrosine kinase receptor for stem cell factor (SCF)], which is expressed and functional in differentiating spermatogonia of the postnatal testis, in which c-kit is essential for pre-meiotic proliferation; and (2) tr-kit, an intracellular protein which is specifically accumulated during spermiogenesis through the use of an alternative intronic promoter, and which is able to trigger mouse egg activation when microinjected into the cytoplasm of metaphase II arrested oocytes. Here, we summarize the most recent findings about the molecular pathways through which c-kit regulates cell cycle progression in mitotic germ cells, and those through which sperm-derived tr-kit triggers parthenogenetic completion of meiosis II and pronuclear formation in microinjected mouse eggs.
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Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
Dolci, S
Pellegrini, M
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Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
Pellegrini, M
Di Agostino, S
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Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
Di Agostino, S
Geremia, R
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Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
Geremia, R
Rossi, P
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Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
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Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
Dolci, S
Pellegrini, M
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机构:
Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
Pellegrini, M
Di Agostino, S
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Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
Di Agostino, S
Geremia, R
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h-index: 0
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Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy
Geremia, R
Rossi, P
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机构:
Univ Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, ItalyUniv Roma Tor Vergata, Sezione Anat, Dipartimento Sanita Pubbl & Biol Cellulare, I-00173 Rome, Italy