Inhibitory activity on lipid peroxidation of extracts from marine brown alga

Several extracts from marine brown alga Sargassum micracanthum (Kuetzing) Endlicher were screened for their inhibitory activity on lipid peroxidation. In an in vitro study, methanol extract (Sm-M), chloroform/methanol (3:1) extract and ethyl acetate fraction of Sm-M inhibited lipid peroxidation. in rat liver homogenates. The IC50 values were 0.70, 0.70 and 0.37 mug/mL, respectively. These inhibitions were stronger than vitamine C and E. These extracts showed reductive activity on DPPH, the IC50 values were 34, 37 and 11 mug/mL, respectively. In an in vivo study, Sm-M had the effect on CCl4 induced liver injury in rats and Sm-M (120-1200 mg/kg, p.o.) lowered dose-dependently the level of lipid peroxidation in liver. Copyright (C) 2003 John Wiley Sons, Ltd.