White Matter in Aging and Cognition: A Cross-Sectional Study of Microstructure in Adults Aged Eighteen to Eighty-Three

被引:144
作者
Bendlin, Barbara B. [1 ,2 ]
Fitzgerald, Michele E. [1 ,2 ]
Ries, Michele L. [1 ,2 ]
Xu, Guofan [1 ,2 ]
Kastman, Erik K. [1 ,2 ]
Thiel, Brent W. [1 ,2 ]
Rowley, Howard A. [3 ]
Lazar, Mariana [4 ]
Alexander, Andrew L. [5 ,6 ,7 ]
Johnson, Sterling C. [1 ,2 ]
机构
[1] William S Middleton Mem Vet Adm Med Ctr, Geriatr Res Educ & Clin Ctr, Madison, WI USA
[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI USA
[3] Univ Wisconsin, Sch Med & Publ Hlth, Dept Radiol, Madison, WI USA
[4] NYU, Sch Med, Dept Radiol, New York, NY USA
[5] Univ Wisconsin, Dept Med Phys, Sch Med & Publ Hlth, Madison, WI 53706 USA
[6] Univ Wisconsin, Dept Psychiat, Sch Med & Publ Hlth, Madison, WI 53706 USA
[7] Waisman Lab Brain Imaging & Behav, Madison, WI USA
关键词
ANTERIOR THALAMIC NUCLEI; DIFFUSION-TENSOR; ALZHEIMERS-DISEASE; NEUROPSYCHOLOGICAL PERFORMANCE; FRACTIONAL ANISOTROPY; LONGITUDINAL CHANGES; CEREBRAL-CORTEX; FAMILY-HISTORY; WORKING-MEMORY; CELL COUNTS;
D O I
10.1080/87565641003696775
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040206 [发展心理学];
摘要
Structural brain change and concomitant cognitive decline are the seemingly unavoidable escorts of aging. Despite accumulating studies detailing the effects of age on the brain and cognition, the relationship between white matter features and cognitive function in aging have only recently received attention and remain incompletely understood. White matter microstructure can be measured with diffusion tensor imaging (DTI), but whether DTI can provide unique information on brain aging that is not explained by white matter volume is not known. In the current study, the relationship between white matter microstructure, age, and neuropsychological function was assessed using DTI in a statistical framework that employed white matter volume as a voxel-wise covariate in a sample of 120 healthy adults across a broad age range (18-83). Memory function and executive function were modestly correlated with the DTI measures while processing speed showed the greatest extent of correlation. The results suggest that age-related white matter alterations underlie age-related declines in cognitive function. Mean diffusivity and fractional anisotropy in several white matter brain regions exhibited a nonlinear relationship with age, while white matter volume showed a primarily linear relationship with age. The complex relationships between cognition, white matter microstructure, and white matter volume still require further investigation.
引用
收藏
页码:257 / 277
页数:21
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