Asymmetric cyclopropanation of styrene catalyzed by Cu-(chiral Schiff-base) complexes

被引：59

作者：

Li, ZN ^{[1
]}

Liu, GS ^{[1
]}

Zheng, Z ^{[1
]}

Chen, HL ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

TETRAHEDRON | 2000年 / 56卷 / 37期

关键词：

asymmetric cyclopropanation; styrene; Schiff base;

D O I：

10.1016/S0040-4020(00)00623-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric cyclopropanation of olefins was carried out with chiral copper-Schiff base complexes derived from copper acetate monohydrate, substituted salicylaldehydes and a chiral amino alcohol. Substituents on salicylaldehyde framework demonstrate a significant effect on the steroselectivities. Those with electron-withdrawing properties enhance the selectivities, whereas bulky sustituents in ortho position to the phenol hydroxy group decrease the selectivities. An ee of more than 98% was achieved for the reaction of styrene with diazoacetate. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7187 / 7191

页数：5

共 27 条

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