Identification of potent and broad-spectrum antibiotics from SAR studies of a synthetic vancomycin analogue

被引：19

作者：

Ahrendt, KA

Olsen, JA

Wakao, M

Trias, J

Ellman, JA ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Ctr New Direct Organ Synth, Berkeley, CA 94720 USA

[2] Versicor Inc, Fremont, CA 94555 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00243-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dimeric vancomycin analogues based on a lead compound identified from a library of synthetic analogues of vancomycin have up to 60-fold greater activity than vancomycin against vancomycin-resistant Enterococcus faecium (VRE, VanA phenotype). Simplified analogues have also been prepared and found to maintain activity against VRE and have broad-spectrum antibiotic activity. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：1683 / 1686

页数：4

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