MHC class II genes in HCV viral clearance of hepatitis C infected Hispanic patients

被引：16

作者：

Azocar, J

Clavijo, OP

Yunis, EJ

机构：

[1] Harvard Univ, Dana Farber Canc Inst, Sch Med, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[2] Northgate Med, Springfield, MA USA

来源：

HUMAN IMMUNOLOGY | 2003年 / 64卷 / 01期

关键词：

HCV; MHC; HLA; Hispanics; Puerto Rican;

D O I：

10.1016/S0198-8859(02)00722-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The frequency of class 11 human leukocyte antigen (HLA) alleles in 112 infected patients of Hispanic ancestry with serology positive for hepatitis C virus (HCV) was investigated. Our studies failed to demonstrate significant association between class 11 HLA alleles and the outcome of HCV infection: chronic viremia versus spontaneous viral clearance. Our results suggest that the genes responsible for the outcome are unknown, so far, and those HLA associations reported in several ethnic groups may represent genetic markers in non-random association with the responsible genes involved in determining viral clearance or chronic viremia following HCV infection. (C) American Society for Histocompatibility and Immunogenetics, 2003. Published by Elsevier Science Inc.

引用

收藏

页码：99 / 102

页数：4

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