Caenorhabditis elegans senses protons through amphid chemosensory neurons:: proton signals elicit avoidance behavior

被引：45

作者：

Sambongi, Y ^{[1
]}

Takeda, K ^{[1
]}

Wakabayashi, T ^{[1
]}

Ueda, I ^{[1
]}

Wada, Y ^{[1
]}

Futai, M ^{[1
]}

机构：

[1] Osaka Univ, Japan Sci & Technol Corp,CREST, Inst Sci & Ind Res, Div Biol Sci, Osaka 5670047, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 10期

关键词：

acidic pH; avoidance behavior; C; elegans; chemosensory neurons; laser microsurgery;

D O I：

10.1097/00001756-200007140-00033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Acidic pH is known to cause pain sensation through nociceptive neurons as well as taste transduction in mammals. Caenorhabditis elegans avoids an acidic environment (pH lower than similar to 4.0) formed by organic or inorganic acids. This avoidance behavior was dependent on multiple amphid chemosensory neurons, and inhibited by a mutation of capsaicin receptor homologue, and by the addition of amiloride and ruthenium red (inhibitors of proton-gated Na+ channels and capsaicin receptors, respectively). These results indicate that C. elegans recognizes protons as a nociceptive stimulus, through multiple neurons, which elicits avoidance behavior. It is of special interest that a system similar to that of mammalian signal transduction is responsible for this nematode's acid avoidance. NeuroReport 11:2229-2232 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：2229 / 2232

页数：4

共 21 条

[1] CHEMOSENSORY NEURONS WITH OVERLAPPING FUNCTIONS DIRECT CHEMOTAXIS TO MULTIPLE CHEMICALS IN C-ELEGANS [J].