Future research directions in acute lung injury - Summary of a National Heart, Lung, and Blood Institute working group

被引:418
作者
Matthay, MA
Zimmerman, GA
Esmon, C
Bhattacharya, J
Coller, B
Doerschuk, CM
Floros, J
Gimbrone, MA
Hoffman, E
Hubmayr, RD
Leppert, M
Matalon, S
Munford, R
Parsons, P
Slutsky, AS
Tracey, KJ
Ward, P
Gail, DB
Harabin, AL
机构
[1] NHLBI, Div Lung Dis, Bethesda, MD 20892 USA
[2] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA
[3] Univ Utah, Program Human Mol Biol & Genet, Salt Lake City, UT USA
[4] Univ Utah, Dept Human Genet, Salt Lake City, UT USA
[5] Oklahoma Med Res Fdn, Cardiovasc & Biol Res Program, Howard Hughes Med Inst, Oklahoma City, OK USA
[6] Mayo Clin & Mayo Fdn, Crit Care Serv, Rochester, MI USA
[7] N Shore LIJ Res Inst, Lab Biomed Sci, Manhasset, NY USA
[8] Columbia Univ Coll Phys & Surg, Dept Med & Physiol, New York, NY USA
[9] Rockefeller Univ, Dept Blood & Vasc Biol, New York, NY USA
[10] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA
[11] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol & Pediat, Hershey, PA USA
[12] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Excellence Vasc Biol, Boston, MA USA
[13] Childrens Natl Med Ctr, Res Ctr Genet Med, Washington, DC 20010 USA
[14] Univ Alabama Birmingham, Dept Anesthesiol, Birmingham, AL USA
[15] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA
[16] Univ Vermont, Dept Pulm & Crit Care Med, Burlington, VT USA
[17] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[18] Univ Toronto, St Michaels Hosp, Interdepartmental Div Crit Care Med, Toronto, ON M5B 1W8, Canada
[19] Univ Toronto, St Michaels Hosp, Dept Med, Toronto, ON M5B 1W8, Canada
关键词
pulmonary inflammation; critical care; genomics; pulmonary; edema; acute respiratory distress syndrome;
D O I
10.1164/rccm.200208-966WS
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema and inflammation. The development of ALI/ARDS is associated with several clinical disorders including direct pulmonary injury from pneumonia and aspiration as well as indirect pulmonary injury from trauma, sepsis, and other disorders such as acute pancreatitis and drug overdose. Although mortality from AWARDS has decreased in the last decade, it remains high. Despite two major advances in treatment, low V-T ventilation for ALI/ARDS and activated protein C for severe sepsis (the leading cause of ALI/ARDS), additional research is needed to develop specific treatments and improve understanding of the pathogenesis of these syndromes. The NHLBI convened a working group to develop specific recommendations for future ALI/ARDS research. Improved understanding of disease heterogeneity through use of evolving biologic, genomic, and genetic approaches should provide major new insights into pathogenesis of ALI. Cellular and molecular methods combined with animal and clinical studies should lead to further progress in the detection and treatment of this complex disease.
引用
收藏
页码:1027 / 1035
页数:9
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