Preparation of the 4-hydroxytryptamine scaffold via palladium-catalyzed cyclization: A practical and versatile synthesis of psilocin

被引：50

作者：

Gathergood, N

Scammells, PJ

机构：

[1] Monash Univ, Victorian Coll Pharm, Dept Med Chem, Parkville, Vic 3052, Australia

[2] Deakin Univ, Sch Biol & Chem Sci, Geelong, Vic 3217, Australia

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 06期

关键词：

D O I：

10.1021/ol0341039

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 4-hydroxytryptamine scaffold of psilocin was successfully prepared via palladium-catalyzed cyclization of protected N-tert-butoxycarbonyl-2-iodo-3-methoxyaniline and an appropriately substituted silyl acetylene. Removal of the protecting groups afforded psilocin in good yield.

引用

页码：921 / 923

页数：3

共 27 条

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[2]

Brown R.T., 1979, COMPREHENSIVE ORGANI, V4, P411

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