Suppressor T cells: Rebirth, function and homeostasis

被引:54
作者
Shevach, EM [1 ]
机构
[1] NIAID, Immunol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/S0960-9822(00)00617-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A minor subpopulation of CD4(+) T cells that co express the cell-surface molecule CD25 has emerged as the major population of T cells responsible for downregulation of the immune response and prevention of autoimmunity. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:R572 / R575
页数:4
相关论文
共 12 条
  • [1] Bachmann MF, 1999, J IMMUNOL, V163, P1128
  • [2] Control of immune pathology by regulatory T cells
    Mason, D
    Powrie, F
    [J]. CURRENT OPINION IN IMMUNOLOGY, 1998, 10 (06) : 649 - 655
  • [3] Regulatory CD4 T cells:: expression of IL-2Rα chain, resistance to clonal deletion and IL-2 dependency
    Papiernik, M
    de Moraes, ML
    Pontoux, C
    Vasseur, F
    Pénit, C
    [J]. INTERNATIONAL IMMUNOLOGY, 1998, 10 (04) : 371 - 378
  • [4] PENHALE WJ, 1976, CLIN EXP IMMUNOL, V25, P6
  • [5] READ S, 2000, IN PRESS J EXP MED
  • [6] SAKAGUCHI S, 1995, J IMMUNOL, V155, P1151
  • [7] Sakaguchi Shimon, 1994, P203
  • [8] B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes
    Salomon, B
    Lenschow, DJ
    Rhee, L
    Ashourian, N
    Singh, B
    Sharpe, A
    Bluestone, JA
    [J]. IMMUNITY, 2000, 12 (04) : 431 - 440
  • [9] Peripheral autoantigen induces regulatory T cells that prevent autoimmunity
    Seddon, B
    Mason, D
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) : 877 - 881
  • [10] Regulatory T cells in autoimmmunity
    Shevach, EM
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 : 423 - 449