Triplex DNA and human disease

被引：45

作者：

Bissler, John J.

机构：

[1] Cincinnati Childrens Hosp, Med Ctr, Clark D W Chair Nephrol, Dept PediatDiv Nephrol, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp, Med Ctr, Div Hypertens, Cincinnati, OH 45229 USA

[3] Univ Cincinnati, Coll Med, Cincinnati, OH USA

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2007年 / 12卷

关键词：

DNA triplex; autosomal dominant polycystic kidney disease; tuberous sclerosis complex; sickle cell disease; persistence of fetal hemoglobin; Friedreich's ataxia; lymphoma; review;

D O I：

10.2741/2408

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutagenesis is the fulcrum for the balance between the fidelity of the genetic code and evolution. While there are an enormous number of extrinsic factors driving mutagenesis, alternative DNA secondary structure is one of the intrinsic components that impacts regional genomic stability. Some alternative DNA structures are associated with human diseases, and this review focuses on disease-associated polypurine.polypyrimidine mirror repeat sequences.

引用

页码：4536 / 4546

页数：11

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