Eight-year survival after advanced gastric cancer treated with S-1 followed by surgery

被引：18

作者：

Hijioka, Susumu ^{[1
]}

Chin, Keisho ^{[1
]}

Seto, Yasuyuki ^{[2
]}

Yamamoto, Noriko ^{[3
]}

Hatake, Kiyohiko ^{[1
]}

机构：

[1] JFCR, Canc Inst Hosp, Dept Med Oncol, Koto Ku, Tokyo 1358550, Japan

[2] JFCR, Canc Inst Hosp, Dept Surg, Koto Ku, Tokyo 1358550, Japan

[3] JFCR, Canc Inst Hosp, Dept Pathol, Koto Ku, Tokyo 1358550, Japan

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 22期

关键词：

S-1; Lymph node metastasis; Gastric cancer; Gastrectomy; PHASE-III TRIAL; PLUS CISPLATIN; FLUOROURACIL; ADENOCARCINOMA; CHEMOTHERAPY;

D O I：

10.3748/wjg.v16.i22.2824

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

We report a case of advanced gastric cancer, with cervical, axillary, and abdominal paraaortic lymph node metastases, that was successfully treated with chemotherapy and surgery. The disease was initially considered unresectable, and the patient was treated with orally administered S-1. Chemotherapy was effective, and all lymph node metastases disappeared after 6 courses. After 27 mo of chemotherapy, the patient underwent curative surgery, with subtotal gastrectomy and lymph node dissection. Histopathological examination revealed many viable poorly differentiated adenocarcinoma cells in the stomach, but no cancer cells in the lymph nodes. The patient is alive, without recurrence, 8 years later. This, therefore, is a case report of an 8-year survivor of advanced gastric cancer with distant lymph node metastasis. (C) 2010 Baishideng. All rights reserved.

引用

页码：2824 / 2827

页数：4

共 15 条

[1]

Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin:: A study of the arbeitsgemeinschaft internistische onkologie [J].

Al-Batran, Salah-Eddin ;

Hartmann, Joerg Thomas ;

Probst, Stephan ;

Schmalenberg, Harald ;

Hollerbach, Stephan ;

Hofheinz, Ralf ;

Rethwisch, Volker ;

Seipelt, Gernot ;

Homann, Nils ;

Wilhelm, Gerhard ;

Schuch, Gunter ;

Stoehlmacher, Jan ;

Derigs, Hans Guenter ;

Hegewisch-Becker, Susanna ;

Grossmann, Johannes ;

Pauligk, Claudia ;

Atmaca, Akin ;

Bokemeyer, Carsten ;

Knuth, Alexander ;

Jaeger, Elke .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (09) :1435-1442

[2]

Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomised phase 3 study [J].

Boku, Narikazu ;

Yamamoto, Seiichiro ;

Fukuda, Haruhiko ;

Shirao, Kuniaki ;

Doi, Toshihiko ;

Sawaki, Akira ;

Koizumi, Wasaburo ;

Saito, Hiroshi ;

Yamaguchi, Kensei ;

Takiuchi, Hiroya ;

Nasu, Junichiro ;

Ohtsu, Atsushi .

LANCET ONCOLOGY, 2009, 10 (11) :1063-1069

[3]

Advances in the treatment of patients with gastric adenocarcinoma [J].

Foukakis, Theodoros ;

Lundell, Lars ;

Gubanski, Michael ;

Lind, Pehr A. .

ACTA ONCOLOGICA, 2007, 46 (03) :277-285

[4]

THE 2ND BRITISH STOMACH-CANCER GROUP TRIAL OF ADJUVANT RADIOTHERAPY OR CHEMOTHERAPY IN RESECTABLE GASTRIC-CANCER - 5-YEAR FOLLOW-UP [J].

HALLISSEY, MT ;

DUNN, JA ;

WARD, LC ;

ALLUM, WH ;

ARNOTT, S ;

BAKER, P ;

BROOKES, VS ;

CRAVEN, JL ;

ELLIS, DJ ;

FIELDING, JWL ;

FAGG, SL ;

HOCKEY, MS ;

LEVISON, D ;

JONES, BG ;

KELLY, K ;

MASON, MC ;

MINAWA, A ;

MCADAM, A ;

TIMOTHY, A ;

WATERHOUSE, JAH ;

WINSEY, S ;

WRIGLEY, PFM .

LANCET, 1994, 343 (8909) :1309-1312

[5]

An oral anticancer drug, TS-1, enabled a patient with advanced gastric cancer with Virchow's metastasis to receive curative resection [J].

Iwazawa T. ;

Kinuta M. ;

Yano H. ;

Matsui S. ;

Tamagaki S. ;

Yasue A. ;

Okada K. ;

Kanoh T. ;

Tono T. ;

Nakano Y. ;

Okamoto S. ;

Monden T. .

Gastric Cancer, 2002, 5 (2) :96-101

[6]

*JAP GASTR CANC AS, 2004, GASTR CANC TREATM GU, P22

[7]

Japanese gastric cancer association, 1998, GASTRIC CANCER, V1, P20

[8]

Kajihara K, 1998, Gan To Kagaku Ryoho, V25, P585

[9]

S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial [J].

Koizumi, Wasaburo ;

Narahara, Hiroyuki ;

Hara, Takuo ;

Takagane, Akinori ;

Akiya, Toshikazu ;

Takagi, Masakazu ;

Miyashita, Kosei ;

Nishizaki, Takashi ;

Kobayashi, Osamu ;

Takiyama, Wataru ;

Toh, Yasushi ;

Nagaie, Takashi ;

Takagi, Seiichi ;

Yamamura, Yoshitaka ;

Yanaoka, Kimihiko ;

Orita, Hiroyuki ;

Takeuchi, Masahiro .

LANCET ONCOLOGY, 2008, 9 (03) :215-221

[10]

Randomized phase III trial of fluorouracil alone versus fluorouracil plus cisplatin versus uracil and tegafur plus mitomycin in patients with unresectable, advanced gastric cancer: The Japan Clinical Oncology Group Study (JCOG9205) [J].

Ohtsu, A ;

Shimada, Y ;

Shirao, K ;

Boku, N ;

Hyodo, I ;

Saito, H ;

Yamamichi, N ;

Miyata, Y ;

Ikeda, N ;

Yamamoto, S ;

Fukuda, H ;

Yoshida, S .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (01) :54-59

← 1 2 →