No association of Vacuolar protein sorting 26 polymorphisms with Alzheimer's disease

被引：8

作者：

Riemenschneider, M.

Schoepfer-Wendels, A.

Friedrich, P.

Konta, L.

Laws, S. M.

Mueller, J. C.

Kurz, A.

Foerstl, H.

机构：

[1] Tech Univ Munich, Lab Neurochem & Neurogenet, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

[2] Edith Cowan Univ, Sir James McCusker Alzheimers Dis Res Unit, Sch Biomed & Sports Sci, Joondalup, Australia

[3] Tech Univ Munich, Inst Med Stat & Epidemiol, Munich, Germany

[4] Hertie Inst Clin Brain Res, Tubingen, Germany

来源：

NEUROBIOLOGY OF AGING | 2007年 / 28卷 / 06期

关键词：

VPS26; Alzheimer's disease; genetic analysis; association study;

D O I：

10.1016/j.neurobiolaging.2006.05.009

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Using a case-control sample we evaluated a possible involvement of the Vacuolar protein sorting 26 (VPS26) gene in the pathogenesis of AD. VPS26 located at 10q22.1 denotes a retromer subunit functionally involved in the cellular trafficking of Memapsin 2 (BACE). Genotyping of eight single nucleotide polymorphisms covering the complete VPS26 gene and haplotypic analysis revealed no association with AD. Thus, we conclude that VPS26 can be excluded as a major positional and functional candidate gene conferring risk to AD. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：883 / 884

页数：2

共 8 条

[1] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[2] Reconstitution of γ-secretase activity [J].

Edbauer, D ;

Winkler, E ;

Regula, JT ;

Pesold, B ;

Steiner, H ;

Haass, C .

NATURE CELL BIOLOGY, 2003, 5 (05) :486-488

[3] Linkage of plasma Aβ42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees [J].

Ertekin-Taner, N ;

Graff-Radford, N ;

Younkin, LH ;

Eckman, C ;

Baker, M ;

Adamson, J ;

Ronald, J ;

Blangero, J ;

Hutton, M ;

Younkin, SG .

SCIENCE, 2000, 290 (5500) :2303-+

[4] MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].

FOLSTEIN, MF ;

FOLSTEIN, SE ;

MCHUGH, PR .

JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198

[5] GGA proteins mediate the recycling pathway of memapsin 2 (BACE) [J].

He, XY ;

Li, F ;

Chang, WP ;

Tang, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (12) :11696-11703

[6]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[7] The future of association studies: Gene-based analysis and replication [J].

Neale, BM ;

Sham, PC .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (03) :353-362

[8] β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE [J].

Vassar, R ;

Bennett, BD ;

Babu-Khan, S ;

Kahn, S ;

Mendiaz, EA ;

Denis, P ;

Teplow, DB ;

Ross, S ;

Amarante, P ;

Loeloff, R ;

Luo, Y ;

Fisher, S ;

Fuller, L ;

Edenson, S ;

Lile, J ;

Jarosinski, MA ;

Biere, AL ;

Curran, E ;

Burgess, T ;

Louis, JC ;

Collins, F ;

Treanor, J ;

Rogers, G ;

Citron, M .

SCIENCE, 1999, 286 (5440) :735-741

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