Failure of pentavalent antimony in visceral leishmaniasis in India: Report from the center of the Indian epidemic

被引：499

作者：

Sundar, S

More, DK

Singh, MK

Singh, VP

Sharma, S

Makharia, A

Kumar, PCK

Murray, HW

机构：

[1] Banaras Hindu Univ, Inst Med Sci, Kala Azar Med Res Ctr, Varanasi 221005, Uttar Pradesh, India

[2] Cornell Univ, Weill Med Coll, Dept Med, New York, NY USA

来源：

CLINICAL INFECTIOUS DISEASES | 2000年 / 31卷 / 04期

关键词：

D O I：

10.1086/318121

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In India, 320 patients with visceral leishmaniasis (209 in the state of Bihar and 11 in the neighboring state of Uttar Pradesh) received identical pentavalent antimony (Sb) treatment. Sb induced long-term cure in 35% (95% confidence interval [CI], 28-42%) of those in Bihar versus 86% (95% CI, 79%-93%) of those in Uttar Pradesh, In Bihar, the center of the Indian epidemic, traditional Sb treatment should be abandoned.

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页码：1104 / 1107

页数：4

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