The role of MicroRNAs in Osteoclasts and Osteoporosis

被引：180

作者：

Tang, Peifu ^{[1
]}

Xiong, Qi ^{[1
]}

Ge, Wei ^{[2
,3
]}

Zhang, Lihai ^{[1
]}

机构：

[1] Chinese PLA, Gen Hosp, Dept Orthoped, Beijing, Peoples R China

[2] Peking Union Med Coll, Sch Basic Med, Natl Key Lab Med Mol Biol, Inst Basic Med Sci, Beijing 100021, Peoples R China

[3] Peking Union Med Coll, Sch Basic Med, Dept Immunol, Inst Basic Med Sci, Beijing 100021, Peoples R China

来源：

RNA BIOLOGY | 2014年 / 11卷 / 11期

基金：

中国国家自然科学基金;

关键词：

MicroRNA; osteoclast; osteoporosis; GM-CSF; Granulocyte macrophage colony-stimulating factor; MiRNA; microRNA; 3'-UTR; 3' untranslated region; BMMs; bone marrow macrophages; PDCD4; programmed cell death 4; FasL; Fas ligand; PIO; particle-induced osteolysis; Calcr; calcitonin receptor; RDX; radixin; M-RIP; myosin phosphatase-Rho interacting protein; ITGA5; integrin; 5; Fzd3; frizzled; 3; ALP; alkaline phosphatase; TRAP; tartrate-resistant acid phosphatase; CXCL11; chemokine (C-X-C motif) ligand 11; CXCR3; chemokine (C-X-C motif) receptor 3; SLC39A1; solute carrier family (zinc transporter) member 1; TRAF6; TNF receptor-associated factor 6; OVX; ovariectomy; MAFB; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B; CBL; Casitas B-lineage lymphoma proto-oncogene; PAG1; phosphoprotein associated with glycosphingolipid microdomains; TOB2; transducer of ERBB2; sICAM1; soluble intracellular adhesion molecule; RHEUMATOID-ARTHRITIS; REGULATES OSTEOCLASTOGENESIS; DIFFERENTIAL EXPRESSION; GENE-EXPRESSION; BONE-RESORPTION; DOWN-REGULATION; RAW264.7; CELLS; STEM-CELLS; MIR-21; RANKL;

D O I：

10.1080/15476286.2014.996462

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusive. MicroRNAs (miRNAs) are novel regulatory factors that play an important role in numerous cellular processes, including cell differentiation and apoptosis, by post-transcriptional regulation of genes. Recently, a number of studies have revealed that miRNAs participate in bone homeostasis, including osteoclastic bone resorption, which sheds light on the mechanisms underlying osteoclast differentiation. In this review, we highlight the miRNAs involved in regulating osteoclast differentiation and bone resorption, and their roles in osteoporosis.

引用

页码：1355 / 1363

页数：9

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