Genetic polymorphism of drug metabolizing enzymes:: New mutations in CYP2D6 and CYP2A6 genes in Japanese

被引：45

作者：

Yokoi, T

Kamataki, T

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Div Drug Metab, Sapporo, Hokkaido 060, Japan

[2] Kanazawa Univ, Fac Pharmaceut Sci, Div Drug Metab, Kanazawa, Ishikawa 920, Japan

来源：

PHARMACEUTICAL RESEARCH | 1998年 / 15卷 / 04期

关键词：

genetic polymorphism; phenotype; drug metabolism; genotype; cytochrome P450; pharmacogenetics; clinical pharmacology;

D O I：

10.1023/A:1011913407147

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Genetic polymorphism of drug metabolizing enzymes, particularly cytochrome P450 (CYP), is an important cause of adverse drug reactions. Multiple gene mutations in CYP have been shown to be phenotype. The occurrence of genetic polymorphism has been seen in genes for CYP1A1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A5. This review discusses the molecular mechanism of two genetic polymorphisms, debrisoquine/sparteine (CYP2D6) coumarin (CYP2A6) polymorphisms. In addition, elucidation of gene mutations of CYP2D6 and CYP2A6 in Japanese will be discussed.

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收藏

页码：517 / 524

页数：8

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