How cost-effective is screening for abdominal aortic aneurysms?

被引：52

作者：

Kim, L. G.

Thompson, S. G.

Briggs, A. H.

Buxton, M. J.

Campbell, H. E.

机构：

[1] MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR, Robinson Way

[2] Section of Public Health and Health Policy, University of Glasgow, Glasgow G12 8RZ

[3] Health Economics Research Group, Brunel University, Uxbridge

[4] Health Economics Research Centre, University of Oxford, Department of Public Health, Headington, Oxford OX3 7LF, Old Road Campus

来源：

JOURNAL OF MEDICAL SCREENING | 2007年 / 14卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1258/096914107780154477

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: To provide reliable estimates of the long-term cost-effectiveness of abdominal aortic aneurysm screening in men. Methods: A Markov health economic decision model for screening is described and extrapolated to 30 years. The strategy modelled involves a one-off scan at age 65 years, with annual and three-monthly follow-up scans for small and medium aneurysms, respectively. Referral for elective surgery occurs at an aortic diameter of 5.5 cm. Model parameters are estimated from patient-level data from the UK Multi-centre Aneurysm Screening Study. Model structure is validated on this trial's data, and input parameter uncertainty is addressed by probabilistic sensitivity analysis. Costs and life-years gained are obtained for both screening and no systematic screening strategies. Results: Cost-effectiveness improves dramatically when considered over longer timescales. Taking a 30-year perspective, screening for abdominal aortic aneurysms in men is highly cost-effective at £2320 per life-year gained (95% uncertainty interval: £1600 to £4240). Adjusting life-years for the age-specific health-related quality of life experienced in this population gave a figure of £2970 (95% uncertainty interval: £2030 to £5430) per quality-adjusted life-year gained. The additional cost of screening the UK male population is estimated to be £19m per year. Conclusions: The long-term cost-effectiveness of screening for abdominal aortic aneurysms in men is highly attractive and this evidence provides further support for a national screening programme in the UK.

引用

页码：46 / 52

页数：7

共 29 条

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