XSIP1, a Xenopus zinc finger/homeodomain encoding gene highly expressed during early neural development

被引：46

作者：

van Grunsven, LA

Papin, C

Avalosse, B

Opdecamp, K

Huylebroeck, D

Smith, JC

Bellefroid, EJ

机构：

[1] Univ Louvain VIB, Dept Cell Growth Differentiat & Dev VIB07, B-3000 Louvain, Belgium

[2] Univ Louvain, Lab Mol Biol Celgen, B-3000 Louvain, Belgium

[3] Natl Inst Med Res, Div Dev Biol, London NW7 1AA, England

[4] Free Univ Brussels, IBMM, Mol Embryol Lab, B-6041 Gosselies, Belgium

来源：

MECHANISMS OF DEVELOPMENT | 2000年 / 94卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

delta EF1; neural induction; Smad-interacting protein-1; Smad-interacting protein; transcriptional repressor; Xenopus laevis; zinc finger;

D O I：

10.1016/S0925-4773(00)00318-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have isolated a Xenopus homologue of the zinc finger/homeodomain-containing transcriptional repressor Smad-interacting protein-1 (SIP1) from mouse. XSIP1 is activated at the early gastrula stage and transcription occurs throughout embryogenesis. At the beginning of gastrulation, XSIP1 is strongly expressed in prospective neurectoderm. At the neurula stage, XSIP1 is highly expressed within the neural plate but weakly in the dorsal midline. At later stages of development transcripts are detected primarily within the neural tube and neural crest. In the adult, XSIP1 expression is detected at variable levels in several organs. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：189 / 193

页数：5

共 17 条

[1] X-MyT1, a Xenopus C2HC-type zinc finger protein with a regulatory function in neuronal differentiation [J].