Pituitary adenylate cyclase-activating polypeptide rhythm in the rat pineal gland

被引：22

作者：

Fukuhara, C

Inouye, SIT

Matsumoto, Y

Tsujimoto, G

Aoki, K

Masuo, Y

机构：

[1] Sophia Univ, Inst Life Sci, Tokyo 102, Japan

[2] Yamaguchi Univ, Dept Phys Informat & Biol, Yamaguchi 753, Japan

[3] Takeda Chem Ind Ltd, Div Discovery Res, Ibaraki, Osaka 30042, Japan

[4] Natl Childrens Med Res Ctr, Div Pediat Pharmacol, Tokyo 154, Japan

[5] Toho Univ, Sch Med, Dept Physiol, Tokyo 143, Japan

来源：

NEUROSCIENCE LETTERS | 1998年 / 241卷 / 2-3期

基金：

日本学术振兴会;

关键词：

pituitary adenylate cyclase-activating polypeptide; circadian rhythm; pineal gland; pituitary gland; sandwich-enzyme immunoassay; rat;

D O I：

10.1016/S0304-3940(98)00041-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pituitary adenylate cyclase-activating polypeptide (PACAP) was recently demonstrated to stimulate melatonin synthesis in the rat pineal gland. Circadian rhythms of melatonin concentration are well known. However, it has not been clarified whether PACAP contents in the pineal gland show circadian rhythm. In this study, we measured PACAP contents in the rat pineal gland throughout the day under 12:12 h light-dark cycle or constant dark conditions. A significant fluctuation was observed in the PACAP content under light-dark conditions but not under constant darkness. On the other hand, the pituitary gland showed no significant variation throughout the day under either conditions. These observations suggest that PACAP may participate in the modulation of melatonin synthesis depending on light conditions in the pineal gland. (C) 1998 Published by Elsevier Science Ireland Ltd.

引用

页码：115 / 118

页数：4

共 20 条

[1] TISSUE DISTRIBUTION OF PACAP AS DETERMINED BY RIA - HIGHLY ABUNDANT IN THE RAT-BRAIN AND TESTES [J].