Epilepsy in the elderly

被引:28
作者
Leppik, IE
Birnbaum, A
机构
[1] MINCEP Epilepsy Care, Minneapolis, MN 55416 USA
[2] Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA
关键词
elderly; epilepsy; antiepileptic drugs; pharmacokinetics;
D O I
10.1055/s-2002-36650
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The elderly are the most rapidly growing segment of our population, and onset of epilepsy is higher in this age group than in any other. With advancing age, there are changes in drug absorption, disposition, and binding. In addition, within the elderly are subgroups: (1) elderly healthy, except for epilepsy (EH) and (2) elderly with multiple medical problems (EMMP). This review examines the factors that need to be considered when selecting the appropriate antiepileptic drug (AED) for an elderly person with epilepsy. Both the older and newer AEDs are reviewed.
引用
收藏
页码:309 / 319
页数:11
相关论文
共 69 条
[1]  
[Anonymous], 1990, Epilepsy: frequency, causes and consequences
[2]   DISPOSITION OF ANTIPYRINE AND PHENYTOIN CORRELATED WITH AGE AND LIVER VOLUME IN MAN [J].
BACH, B ;
HANSEN, JM ;
KAMPMANN, JP ;
RASMUSSEN, SN ;
SKOVSTED, L .
CLINICAL PHARMACOKINETICS, 1981, 6 (05) :389-396
[3]   AGE AND PHENYTOIN KINETICS IN ADULT EPILEPTICS [J].
BAUER, LA ;
BLOUIN, RA .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1982, 31 (03) :301-304
[4]   VALPROIC ACID CLEARANCE - UNBOUND FRACTION AND DIURNAL-VARIATION IN YOUNG AND ELDERLY ADULTS [J].
BAUER, LA ;
DAVIS, R ;
WILENSKY, A ;
RAISYS, V ;
LEVY, RH .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 37 (06) :697-700
[5]   PLASMA-PROTEIN BINDING OF DRUGS AS A FUNCTION OF AGE IN ADULT HUMAN SUBJECTS [J].
BENDER, AD ;
POST, A ;
MEIER, JP ;
HIGSON, JE ;
REICHARD, G .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (10) :1711-1713
[6]  
Bohannon AD, 1999, AM J EPIDEMIOL, V149, P1002
[7]   DECREASED PHENYTOIN LEVEL DURING ANTI-NEOPLASTIC THERAPY - A CASE-REPORT [J].
BOLLINI, P ;
RIVA, R ;
ALBANI, F ;
IDA, N ;
CACCIARI, L ;
BOLLINI, C ;
BARUZZI, A .
EPILEPSIA, 1983, 24 (01) :75-78
[8]   PHARMACOKINETICS OF VALPROIC ACID IN YOUNG AND ELDERLY SUBJECTS [J].
BRYSON, SM ;
VERMA, N ;
SCOTT, PJW ;
RUBIN, PC .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 16 (01) :104-105
[9]  
Cloyd J C, 1994, Arch Fam Med, V3, P589, DOI 10.1001/archfami.3.7.589
[10]   SEIZURE ACTIVITY ASSOCIATED WITH ANTIPSYCHOTIC THERAPY [J].
COLD, JA ;
WELLS, BG ;
FROEMMING, JH .
DICP-THE ANNALS OF PHARMACOTHERAPY, 1990, 24 (06) :601-606