Molecular determinants of TRP channel assembly

被引：24

作者：

Lepage, P. K. ^{[1
]}

Boulay, G. ^{[1
]}

机构：

[1] Univ Sherbrooke, Fac Med & Sci Sante, Dept Pharmacol, Sherbrooke, PQ J1H 5N4, Canada

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

关键词：

ankyrin; calcium channel; coned-coil domain; Shaker channel; subunit assembly; transient receptor potential channel (TRP channel);

D O I：

10.1042/BST0350081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium channels play important roles in cellular signalling. TRP (transient receptor potential) channels form a superfamily of calcium channels through which Ca2+ enters the cell. TRPs have six transmembrane segments with a putative pore between the fifth and the sixth segments, and assemble in tetrameric complexes to form functional Ca2+ channels. They are thus similar to K-v (voltage-gated potassium channel) channels in terms of structure and molecular determinants that promote subunit assembly. in this review, the molecular determinants mediating the assembly of Drosophila TRP, TRPC (TRP canonical), TRPV (TRP vanilloid) and K-v channels are described.

引用

页码：81 / 83

页数：3

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