Expanding fields of genetically altered cells in head and neck squamous carcinogenesis

被引：74

作者：

Braakhuis, BJM ^{[1
]}

Leemans, CR ^{[1
]}

Brakenhoff, RH ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Otolaryngol Head & Neck Surg, Sect Tumorbiol, NL-1007 MB Amsterdam, Netherlands

来源：

SEMINARS IN CANCER BIOLOGY | 2005年 / 15卷 / 02期

关键词：

field cancerization; multistep; secondary cancer; squamous; stem cell;

D O I：

10.1016/j.semcancer.2004.08.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent molecular pathology studies in head and neck cancer support a carcinogenesis model in which the development of a field with genetically altered cells plays a central role. This preneoplastic field is of monoclonal origin and expands non-invasively superseding normal epithelium. Clonal divergence and selection within the field ultimately leads to the development of cancer. These fields can be large (over 7 cm diameter) and are often not visible for the surgeon explaining that they may remain after resection of the primary tumor. when not removed, a field is an important risk factor for secondary cancer. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：113 / 120

页数：8

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