Expanding fields of genetically altered cells in head and neck squamous carcinogenesis

被引:72
作者
Braakhuis, BJM [1 ]
Leemans, CR [1 ]
Brakenhoff, RH [1 ]
机构
[1] Vrije Univ Amsterdam, Med Ctr, Dept Otolaryngol Head & Neck Surg, Sect Tumorbiol, NL-1007 MB Amsterdam, Netherlands
关键词
field cancerization; multistep; secondary cancer; squamous; stem cell;
D O I
10.1016/j.semcancer.2004.08.004
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Recent molecular pathology studies in head and neck cancer support a carcinogenesis model in which the development of a field with genetically altered cells plays a central role. This preneoplastic field is of monoclonal origin and expands non-invasively superseding normal epithelium. Clonal divergence and selection within the field ultimately leads to the development of cancer. These fields can be large (over 7 cm diameter) and are often not visible for the surgeon explaining that they may remain after resection of the primary tumor. when not removed, a field is an important risk factor for secondary cancer. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:113 / 120
页数:8
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