Why whey? Camel whey protein as a new dietary approach to the management of free radicals and for the treatment of different health disorders

被引:51
作者
Badr, Gamal [1 ,2 ]
Ramadan, Nancy K. [1 ,3 ]
Sayed, Leila H. [1 ,2 ]
Badr, Badr M. [4 ]
Omar, Hossam M. [1 ]
Selamoglu, Zeliha [5 ]
机构
[1] Assiut Univ, Zool Dept, Fac Sci, Assiut 71516, Egypt
[2] Assiut Univ, Zool Dept, Fac Sci, Lab Immunol & Mol Physiol, Assiut 71516, Egypt
[3] Anim Hlth Res Inst, Assiut Branch, Assiut, Egypt
[4] Atom Energy Author, NCRRT, Dept Radiat Biol, Nasr City, Cairo Governora, Egypt
[5] Nigde Univ, Fac Arts & Sci, Dept Biol, Nigde, Turkey
关键词
Antioxidant; Camel whey protein; Free radicals; Health problems; Inflammation; HERPES-SIMPLEX-VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; MILK-PROTEINS; IN-VITRO; IMMUNOENHANCING PROPERTY; BACTERICIDAL ACTIVITY; ANTIVIRAL ACTIVITIES; HUMAN-PAPILLOMAVIRUS; CANCER CELLS; BOVINE-MILK;
D O I
10.22038/IJBMS.2017.8573
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
100103 [病原生物学]; 100218 [急诊医学];
摘要
The balance between free radicals and antioxidants is an important factor for maintaining health and slowing disease progression. The use of antioxidants, particularly natural antioxidants, has become an important strategy for dealing with this cause of widespread diseases. Natural antioxidants have been used as therapeutic tools against many diseases because they are safe, effective, and inexpensive and are among the most commonly used adjuvants in the treatment of several diseases. Camel whey protein (CWP) is considered a strong natural antioxidant because it decreases oxidative stress, enhances immune system function, and increases glutathione levels. The structure of CWP is very similar to that of other types of whey protein from different types of milk. CWP contains many components, such as lactoferrin (LF), lactalbumin, lactoglobulins, lactoperoxidase, and lysozyme, and is rich in immunoglobulins. However, in contrast to other WPs, CWP lacks beta-lactoglobulin, the main cause of milk allergies in children. The components of CWP have many beneficial effects, including stimulation of both innate and adaptive immunity and anti-inflammatory, anticancer, antibacterial, and antiviral activities. Recently, it has been shown that CWP and its unique components can facilitate the treatment of impaired diabetic wound healing. However, the molecular mechanisms underlying the protective effects of CWP in human and other animal disorders are not fully understood. Therefore, the current review presents a concise summary of the scientific evidence of the beneficial effects of CWP to support its therapeutic use in disease treatment and nutritional intervention.
引用
收藏
页码:338 / 349
页数:12
相关论文
共 121 条
[1]
Dietary supplementation with whey protein and ginseng extract counteracts oxidative stress and DNA damage in rats fed an aflatoxin-contaminated diet [J].
Abdel-Aziem, Sekena H. ;
Hassan, Aziza M. ;
Abdel-Wahhab, Mosaad A. .
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2011, 723 (01) :65-71
[2]
Zero prevalence of diabetes in camel milk consuming Raica community of north-west Rajasthan, India [J].
Agrawal, R. P. ;
Budania, S. ;
Sharma, P. ;
Gupta, Rajeev ;
Kochar, D. K. ;
Panwar, R. B. ;
Sahani, M. S. .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 76 (02) :290-296
[3]
Effect of camel milk on residual β-cell function in recent onset type 1 diabetes [J].
Agrawal, Rajendra P. ;
Saran, Sanjay ;
Sharma, Poornima ;
Gupta, Rajendra P. ;
Kochar, Dhanpat K. ;
Sahani, Mohan S. .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 77 (03) :494-495
[4]
Neurochemical, structural and neurobehavioral evidence of neuronal protection by whey proteins in diabetic albino mice [J].
Ajarem, Jamaan ;
Allam, Ahmed A. ;
Ebaid, Hossam ;
Maodaa, Saleh N. ;
AL-Sobeai, Sanad M. ;
Rady, Ahmed M. ;
Metwalli, Ali ;
Altoom, Naif G. ;
Ibrahim, Khaled Elfakki ;
Sabri, Mohammad I. .
BEHAVIORAL AND BRAIN FUNCTIONS, 2015, 11
[5]
Viral entry mechanisms: cellular and viral mediators of herpes simplex virus entry [J].
Akhtar, Jihan ;
Shukla, Deepak .
FEBS JOURNAL, 2009, 276 (24) :7228-7236
[6]
AlhajOA KA, 2006, EFF BIF BACT LACT TR
[7]
BACTERICIDAL ACTIVITY OF HUMAN LACTOFERRIN - DIFFERENTIATION FROM THE STASIS OF IRON DEPRIVATION [J].
ARNOLD, RR ;
RUSSELL, JE ;
CHAMPION, WJ ;
BREWER, M ;
GAUTHIER, JJ .
INFECTION AND IMMUNITY, 1982, 35 (03) :792-799
[8]
Badr G., 2013, LIPIDS HLTH DIS, V12, P1
[9]
Badr G., 2011, LIPIDS HLTH DIS, V10, P1
[10]
Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process by enhancing the expression of MIP-1α, MIP-2, KC, CX3CL1 and TGF-β in wounded tissue [J].
Badr, Gamal ;
Badr, Badr M. ;
Mahmoud, Mohamed H. ;
Mohany, Mohamed ;
Rabah, Danny M. ;
Garraud, Olivier .
BMC IMMUNOLOGY, 2012, 13