γδ T cell subsets: A link between TCR and function?

被引：46

作者：

O'Brien, Rebecca L. ^{[1
,2
]}

Born, Willi K. ^{[1
,2
]}

机构：

[1] Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO 80206 USA

[2] Univ Colorado, Aurora, CO 80045 USA

来源：

SEMINARS IN IMMUNOLOGY | 2010年 / 22卷 / 04期

关键词：

gamma delta T cells; T cell receptor; Thymus; ESCHERICHIA-COLI INFECTION; COLLAGEN-INDUCED ARTHRITIS; LISTERIA-MONOCYTOGENES; INTERFERON-GAMMA; ALPHA-BETA; IFN-GAMMA; INVARIANT V-GAMMA-6/V-DELTA-1; AIRWAY HYPERRESPONSIVENESS; DEFAULT PRODUCTION; ANTIGEN;

D O I：

10.1016/j.smim.2010.03.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The gamma delta T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because gamma delta T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that gamma delta T cell subsets also appear to be biased to carry out particular functions. This suggests that particular gamma delta TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined gamma delta T cell subsets, and evidence that their functions are predetermined in the thymus. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：193 / 198

页数：6

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