Gly-Pro-Glu protects β-amyloid-induced somatostatin depletion in the rat cortex

被引：24

作者：

Aguado-Liera, D

Martín-Martínez, M

García-López, MT

Arilla-Ferreiro, E

Barrios, V ^{[1
]}

机构：

[1] Univ Autonoma, Dept Endocrinol, E-28009 Madrid, Spain

[2] Univ Autonoma, Res Lab, Hosp Infantil Univ Nino Jesus, E-28009 Madrid, Spain

[3] CSIC, Inst Quim Med, E-28006 Madrid, Spain

[4] Univ Alcala de Henares, Neurobiochem Unit, E-28871 Alcala De Henares, Spain

来源：

NEUROREPORT | 2004年 / 15卷 / 12期

关键词：

adenylyl cyclase; Alzheimer's disease; amyloid beta-peptide; GPE; neuroprotection; somatostatin; temporal cortex;

D O I：

10.1097/00001756-200408260-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of Gly-Pro-Glu (GPE) on the somatostatinergic system of the temporal cortex in annyloid beta-pepticle (Abeta) treated rats was investigated. Intracerebroventricular Abeta25-35 administration for 14 days (300 pmol/day) to ovariectomized rats produced a marked reduction in somatostatin (SRIF) content, SRIF receptor density and reduced the inhibitory effect of SRIF on adenylyl cyclase activity. I.p. injection of three doses (300 mug) of GPE on days 0, 6 and 12 resulted in a partial recovery of the parameters affected by Abeta25-35 administration. These results indicate that GPE may have an in vivo effect protecting the temporal cortical somatostatinergic system from Abeta insult.

引用

页码：1979 / 1982

页数：4

共 26 条

[1] BRAIN SOMATOSTATINERGIC SYSTEM AT LATE PREGNANCY, PARTURITION AND THE EARLY POSTPARTUM PERIOD IN THE RAT [J].