Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder

被引：207

作者：

Schmahl, CG

Vermetten, E

Elzinga, BM

Bremner, JD

机构：

[1] Univ Freiburg, Sch Med, Dept Psychiat & Psychotherapy, D-79104 Freiburg, Germany

[2] Univ Utrecht, Cent Mil Hosp, Ctr Med, Dept Psychiat, Utrecht, Netherlands

[3] Leiden Univ, Dept Clin Psychol, Leiden, Netherlands

[4] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA

[5] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA

[6] Emory Univ, Sch Med, Ctr Positron Emiss Tomog, Atlanta, GA 30322 USA

[7] Atlanta VAMC, Decatur, GA USA

来源：

PSYCHIATRY RESEARCH-NEUROIMAGING | 2003年 / 122卷 / 03期

关键词：

early life stress; glucocorticoids; post-traumatic stress disorder;

D O I：

10.1016/S0925-4927(03)00023-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Borderline personality disorder (BPD) is a common disorder associated with emotional dysregulation and other symptoms that have been hypothesized to be related to dysfunction of limbic brain areas including hippocampus and amygdala. The purpose of this study was to measure hippocampal and amygdala volumes in BPD. Hippocampal and amygdala volumes were measured with magnetic resonance imaging (MRI) in 10 patients with BPD and 23 control subjects. Patients with BPD had a 21.9% smaller mean amygdala volume and a 13.1% smaller hippocampal volume, compared to controls. These findings are consistent with the hypothesis that alterations in the hippocampus and amygdala are associated with BPD. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：193 / 198

页数：6

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