A decade of hypocretins: past, present and future of the neurobiology of arousal

被引：27

作者：

de Lecea, L. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA

来源：

ACTA PHYSIOLOGICA | 2010年 / 198卷 / 03期

关键词：

addiction; hypothalamus; optogenetics; orexin; sleep; wakefulness; MELANIN-CONCENTRATING HORMONE; HYPOTHALAMIC OREXIN NEURONS; OREXIN/HYPOCRETIN NEURONS; NEUROPEPTIDE-Y; MESSENGER-RNAS; SLEEP; NARCOLEPSY; ACTIVATION; PEPTIDES; RECEPTOR;

D O I：

10.1111/j.1748-1716.2009.02004.x

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

In 1998, two groups independently identified the hypocretins, also known as orexins, as two hypothalamic peptides derived from the same precursor expressed in a few thousand neurones restricted to the perifornical area. A decade later, an amazing set of discoveries has demonstrated a key role for this neurotransmitter system in arousal and beyond. Here I review some of the experiments that led to these discoveries and the implications in the neurobiology of the hypothalamus and our understanding of brain arousal.

引用

页码：203 / 208

页数：6

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