Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae

被引：100

作者：

Santagati, M

Iannelli, F

Oggioni, MR

Stefani, S

Pozzi, G

机构：

[1] Univ Siena, Dipartimento Biol Mol, Sez Microbiol, I-53100 Siena, Italy

[2] Univ Catania, Dipartimento Sci Microbiol, Catania, Italy

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 09期

关键词：

D O I：

10.1128/AAC.44.9.2585-2587.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).

引用

页码：2585 / 2587

页数：3

共 41 条

[1] SEQUENCE OF A STAPHYLOCOCCAL PLASMID GENE, VGA, ENCODING A PUTATIVE ATP-BINDING PROTEIN INVOLVED IN RESISTANCE TO VIRGINIAMYCIN A-LIKE ANTIBIOTICS
ALLIGNET, J
LONCLE, V
ELSOLH, N
[J]. GENE, 1992, 117 (01) : 45 - 51
[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, SF
Madden, TL
Schaffer, AA
Zhang, JH
Zhang, Z
Miller, W
Lipman, DJ
[J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (17) : 3389 - 3402
[3] Incidence of mefA and mefE genes in viridans group streptococci
Arpin, C
Canron, MH
Maugein, J
Quentin, C
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (09) : 2335 - 2336
[4] Presence of mefA and mefE genes in Streptococcus agalactiae
Arpin, C
Daube, H
Tessier, F
Quentin, C
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (04) : 944 - 946
[5] Emergence of mefA and mefE genes in beta-haemolytic streptococci and pneumococci in France
Arpin, C
Canron, MH
Noury, P
Quentin, C
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 44 (01) : 133 - 134
[6] MOLECULAR-GENETICS OF THE CHLORAMPHENICOL-RESISTANCE TRANSPOSON TN4451 FROM CLOSTRIDIUM-PERFRINGENS - THE TNPX SITE-SPECIFIC RECOMBINASE EXCISES A CIRCULAR TRANSPOSON MOLECULE
BANNAM, TL
CRELLIN, PK
ROOD, JI
[J]. MOLECULAR MICROBIOLOGY, 1995, 16 (03) : 535 - 551
[7] Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships
Brenner, SE
Chothia, C
Hubbard, TJP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) : 6073 - 6078
[8] Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes
Clancy, J
Petitpas, J
DibHajj, F
Yuan, W
Cronan, M
Kamath, AV
Bergeron, J
Retsema, JA
[J]. MOLECULAR MICROBIOLOGY, 1996, 22 (05) : 867 - 879
[9] The resolvase/invertase domain of the site-specific recombinase TnpX is functional and recognizes a target sequence that resembles the junction of the circular form of the Clostridium perfringens transposon Tn4451
Crellin, PK
Rood, JI
[J]. JOURNAL OF BACTERIOLOGY, 1997, 179 (16) : 5148 - 5156
[10] Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains in Italy and heterogeneity of inducibly resistant strains
Giovanetti, E
Montanari, MP
Mingoia, M
Varaldo, PE
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (08) : 1935 - 1940

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