Unselective phenolic coupling of methyl 2-hydroxy-4-methoxy-6-methylbenzoate -: A valuable tool for the total synthesis of natural product families

被引：23

作者：

Drochner, D

Hüttel, W

Nieger, M

Müller, M

机构：

[1] Forschungszentrum Julich, Inst Biotechnol 2, D-52425 Julich, Germany

[2] Univ Bonn, Inst Anorgan Chem, D-53121 Bonn, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 08期

关键词：

D O I：

10.1002/anie.200390247

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One monomeric orsellinate (1) suffices for a highly efficient total synthesis of the dimeric coumarins kotanin, isokotanin A, and desertorin C. The reason is the unselective course of its oxidative phenolic coupling, which leads to three regioisomeric biaryls as precursors of the dimers.

引用

页码：931 / +

页数：4

共 34 条

[1]

Barton D. H. R, 1957, FESTSCHRIFT A STOLL, P117

[2]

BASINSKI W, 1995, POL J CHEM, V69, P376

[3]

BILLEN G, 1988, NATURAL PRODUCTS CHE, V3, P305

[4]

Bringmann G, 2001, PROG CH ORG NAT PROD, V82, P1