Histone variants meet their match

被引：207

作者：

Sarma, K ^{[1
]}

Reinberg, D ^{[1
]}

机构：

[1] Rutgers State Univ, Robert Wood Johnson Med Sch, Howard Hughes Med Inst, Div Nucl Acids Enzymol,Dept Biochem, Piscataway, NJ 08854 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1567

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A fascinating aspect of how chromatin structure impacts on gene expression and cellular identity is the transmission of information from mother to daughter cells, independently of the primary DNA sequence. This epigenetic information seems to be contained within the covalent modifications of histone polypeptides and the distinctive characteristics of variant histone subspecies. There are specific deposition pathways for some histone variants, which provide invaluable mechanistic insights into processes whereby the major histones are exchanged for their more specialized counterparts.

引用

页码：139 / 149

页数：11

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