Synthesis and anti-inflammatory activity of chalcone derivatives

被引：208

作者：

Herencia, F

Ferrándiz, ML ^{[1
]}

Ubeda, A

Domínguez, JN

Charris, JE

Lobo, GM

Alcaraz, MJ

机构：

[1] Univ Valencia, Dept Farmacol, E-46100 Valencia, Spain

[2] Cent Univ Venezuela, Fac Farm, Lab Sintesis Organ, Caracas 1050, Venezuela

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(98)00179-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chalcones and their derivatives were synthesized and evaluated for their anti-inflammatory activity. In vitro, chalcones 2, 4, 8, 10 and 13 inhibited degranulation and 5-lipoxygenase in human neutrophils, whereas 11 behaved as scavenger of superoxide. Only four compounds (4-7) inhibited cyclo-oxygenase-2 activity. The majority of these samples showed anti-inflammatory effects in the mouse air pouch model. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1169 / 1174

页数：6

共 13 条

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