A practical synthesis for the core structure of a family of selective prostaglandin D2 receptor antagonists

被引：10

作者：

Campos, KR ^{[1
]}

Journet, M ^{[1
]}

Cai, DW ^{[1
]}

Kowal, JJ ^{[1
]}

Lee, S ^{[1
]}

Larsen, RD ^{[1
]}

Reider, PJ ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 06期

关键词：

D O I：

10.1021/jo026511g

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A convergent synthesis was developed for the production of the core structure of prostaglandin D-2 receptor antagonists for the treatment of allergic rhinitis. The key steps in this synthesis were a highly diastereoselective alkylation of (+)-nopinone, a chemo- and stereoselective reduction of an oxime to an amine, and a well-controlled reduction of an aminoalkyne to a (Z)-olefin.

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收藏

页码：2338 / 2342

页数：5

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