A burst-based "Hebbian" learning rule at retinogenicu late synapses links retinal waves to activity-dependent refinement

被引:155
作者
Butts, Daniel A. [1 ]
Kanold, Patrick O. [1 ]
Shatz, Carla J. [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
来源
PLOS BIOLOGY | 2007年 / 5卷 / 03期
关键词
D O I
10.1371/journal.pbio.0050061
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Patterned spontaneous activity in the developing retina is necessary to drive synaptic refinement in the lateral geniculate nucleus (LGN). Using perforated patch recordings from neurons in LGN slices during the period of eye segregation, we examine how such burst-based activity can instruct this refinement. Retinogeniculate synapses have a novel learning rule that depends on the latencies between pre- and postsynaptic bursts on the order of one second: coincident bursts produce long-lasting synaptic enhancement, whereas non-overlapping bursts produce mild synaptic weakening. It is consistent with "Hebbian" development thought to exist at this synapse, and we demonstrate computationally that such a rule can robustly use retinal waves to drive eye segregation and retinotopic refinement. Thus, by measuring plasticity induced by natural activity patterns, synaptic learning rules can be linked directly to their larger role in instructing the patterning of neural connectivity.
引用
收藏
页码:651 / 661
页数:11
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