Cp*Ir complex-catalyzed N-heterocyclization of primary amines with diols:: A new catalytic system for environmentally benign synthesis of cyclic amines

被引：244

作者：

Fujita, KI ^{[1
]}

Fujii, T ^{[1
]}

Yamaguchi, R ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto 6068501, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 20期

关键词：

D O I：

10.1021/ol048619j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new efficient method for the N-heterocyclization of primary amines with diols catalyzed by a Cp*Ir complex was developed. A variety of five-, six-, and seven-membered cyclic amines were synthesized in good to excellent yields with the formation of only water as a byproduct. A two-step asymmetric synthesis of (S)-2-phenylpiperidine was also achieved using (R)-1-phenylethylamine as a starting primary amine.

引用

页码：3525 / 3528

页数：4

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