Immunity, Inflammation, and Cancer

被引：8375

作者：

Grivennikov, Sergei I. ^{[1
,2
]}

Greten, Florian R. ^{[3
]}

Karin, Michael ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Sch Med, Dept Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

[3] Tech Univ Munich, Klinikum Rechts Isar, Dept Med 2, D-81675 Munich, Germany

来源：

CELL | 2010年 / 140卷 / 06期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; PROMOTE TUMOR-GROWTH; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; EPITHELIAL-MESENCHYMAL TRANSITION; CHRONIC LYMPHOCYTIC-LEUKEMIA; COLITIS-ASSOCIATED CANCER; NECROSIS-FACTOR-ALPHA; T-CELL RESPONSES; MYELOID CELLS; TGF-BETA;

D O I：

10.1016/j.cell.2010.01.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation also affects immune surveillance and responses to therapy. Immune cells that infiltrate tumors engage in an extensive and dynamic crosstalk with cancer cells, and some of the molecular events that mediate this dialog have been revealed. This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention.

引用

页码：883 / 899

页数：17

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