Fertility: Purinergic receptors and the male contraceptive pill

被引：14

作者：

Dunn, PM ^{[1
]}

机构：

[1] UCL Royal Free & Univ Coll, Sch Med, Auton Neurosci Inst, Dept Anat & Dev Biol, London NW3 2PF, England

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0960-9822(00)00436-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Knockout mice lacking the P2X(1) receptor appear normal, but fail to breed. Analysis of these mutant mice clearly shows that purinergic co-transmission has a physiological role in the vas deferens. These findings also raise the possibility of developing non-hormonal ways of regulating male fertility.

引用

收藏

页码：R305 / R307

页数：3

相关论文

共 12 条

[1] Clinical trial of transdermal testosterone and oral levonorgestrel for male contraception [J].

Büchter, D ;

von Eckardstein, S ;

von Eckardstein, A ;

Kamischke, A ;

Simoni, M ;

Behre, HM ;

Nieschlag, E .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (04) :1244-1249

[2] DO SOME NERVE-CELLS RELEASE MORE THAN ONE TRANSMITTER [J].

BURNSTOCK, G .

NEUROSCIENCE, 1976, 1 (04) :239-248

[3]

Burnstock G, 1996, CIBA F SYMP, V198, P1

[4] ATP RECEPTOR-MEDIATED SYNAPTIC CURRENTS IN THE CENTRAL-NERVOUS-SYSTEM [J].

EDWARDS, FA ;

GIBB, AJ ;

COLQUHOUN, D .

NATURE, 1992, 359 (6391) :144-147

[5] EFFECT OF DRUGS INTERACTING WITH ADRENORECEPTORS AND MUSCARINIC RECEPTORS IN THE EPIDIDYMAL AND PROSTATIC PARTS OF THE HUMAN ISOLATED VAS-DEFERENS [J].

HEDLUND, H ;

ANDERSSON, KE ;

LARSSON, B .

JOURNAL OF AUTONOMIC PHARMACOLOGY, 1985, 5 (03) :261-270

[6] Diinosine pentaphosphate (IP5I) is a potent antagonist at recombinant rat P2X1 receptors [J].

King, BF ;

Liu, M ;

Pintor, J ;

Gualix, J ;

Miras-Portugal, MT ;

Burnstock, G .

BRITISH JOURNAL OF PHARMACOLOGY, 1999, 128 (05) :981-988

[7] Purinergic fast excitatory postsynaptic potentials in myenteric neurons of guinea pig: Distribution and pharmacology [J].

LePard, KJ ;

Messori, E ;

Galligan, JJ .

GASTROENTEROLOGY, 1997, 113 (05) :1522-1534

[8] Reduced vas deferens contraction and male infertility in mice lacking P2X1 receptors [J].

Mulryan, K ;

Gitterman, DP ;

Lewis, CJ ;

Vial, C ;

Leckie, BJ ;

Cobb, AL ;

Brown, JE ;

Conley, EC ;

Buell, G ;

Pritchard, CA ;

Evans, RJ .

NATURE, 2000, 403 (6765) :86-89

[9]

Ralevic V, 1998, PHARMACOL REV, V50, P413

[10] The antagonist trinitrophenyl-ATP reveals co-existence of distinct P2X receptor channels in rat nodose neurones [J].

Thomas, S ;

Virginio, C ;

North, RA ;

Surprenant, A .

JOURNAL OF PHYSIOLOGY-LONDON, 1998, 509 (02) :411-417