Stereochemistry and mechanism of the conversion of 5-aminolaevulinic acid into porphobilinogen catalysed by porphobilinogen synthase

被引：8

作者：

Goodwin, CE ^{[1
]}

Leeper, FJ ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 09期

关键词：

D O I：

10.1039/b302509h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(3R)- and (3S)-Deuteriated forms of 5-aminolaevulinic acid have been synthesised and the (3R)-form shows a significantly larger isotope effect when incubated with porphobilinogen synthase from bovine liver and from Bacillus subtilis; based on this and on available crystal structures, a modified mechanism for the enzymic reaction is proposed.

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页码：1443 / 1446

页数：4

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