Role of cannabinoid CB2 receptors in glucose homeostasis in rats

被引：103

作者：

Bermudez-Silva, Francisco Javier

Sanchez-Vera, Irene

Suarez, Juan

Serrano, Antonia

Fuentes, Esther

Juan-Pico, Pablo

Nadal, Angel

Rodriguez de Fonseca, Fernando

机构：

[1] Hosp Carlos Haya, Fdn IMABIS, E-29010 Malaga, Spain

[2] Univ Miguel Hernandez Elche, Inst Bioingn, E-03202 Alicante, Spain

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2007年 / 565卷 / 1-3期

关键词：

endocannabinoid; cannabinoid receptor; glucose intolerance; diabetes; pancreatic islet;

D O I：

10.1016/j.ejphar.2007.02.066

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Here we show that the activation of cannabinoid CB2 receptors improved glucose tolerance after a glucose load. Blockade of cannabinoid CB2 receptors counteracted this effect, leading to glucose intolerance. Since blockade of cannabinoid CB1 receptors mimics the actions of cannabinoid CB2 receptor agonists, we propose that the endocannabinoid system modulates glucose homeostasis through the coordinated actions of cannabinoid CB1 and CB2 receptors. We also describe the presence of both cannabinoid CB1 and CB2 receptor immunoreactivity in rat pancreatic beta- and non-beta-cells, adding the endocrine pancreas to adipose tissue and the liver as potential sites for endocannabinoid regulation of glucose homeostasis. (c) 2007 Elsevier B.V. All rights reserved.

引用

收藏

页码：207 / 211

页数：5

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