Selegiline in the treatment of Parkinson's disease: its impact on orthostatic hypotension

被引：19

作者：

Bhattacharya, KF

Nouri, S

Olanow, CW

Yahr, MD

Kaufmann, H ^{[1
]}

机构：

[1] CUNY Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA

[2] Guys Kings & St Thomas Sch Med & Dent, London, England

来源：

PARKINSONISM & RELATED DISORDERS | 2003年 / 9卷 / 04期

关键词：

selegiline; blood pressure; autonomic nervous system; Parkinson's disease;

D O I：

10.1016/S1353-8020(02)00053-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Less than a consensus exists as to whether chronic treatment with selegiline in combination with levodopa/carbidopa in patients with Parkinson's disease, is associated with more pronounced orthostatic hypotension than treatment with levodopa/carbidopa alone. To resolve this issue, we compared orthostatic tolerance and autonomic reflexes in 95 patients with Parkinson's disease treated chronically with either selegiline alone (n = 10), levodopa/carbidopa alone (n = 49) or both agents combined (n = 36). Supine heart rate and blood pressure, autonomic cardiovascular reflexes and the frequency and magnitude of orthostatic hypotension were similar in all three treatment groups. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：221 / 224

页数：4

共 46 条

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