The use of bifunctional catalyst systems in the asymmetric addition of alkynylzinc to aldehydes

被引：62

作者：

Kang, YF

Liu, L

Wang, R ^{[1
]}

Yan, WJ

Zhou, YF

机构：

[1] Lanzhou Univ, Sch Life Sci, Dept Biochem Mol Biol, Lanzhou 730000, Peoples R China

[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 19期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/j.tetasy.2004.08.024

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The bifunctional ligand 2a showed a more enhanced reactivity than that of the corresponding amino alcohol ligand in the asymmetric addition of alkynylzinc to benzaldehyde. The bifunctional ligand 2a can catalyze the addition of phenylacetylene to various types of aldehydes including aromatic aldehydes, aliphatic aldehydes, and alpha,beta-unsaturated aldehydes with high enantioselectivity (81-98% ee). The conditions of this catalytic process are both mild and simple. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：3155 / 3159

页数：5

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