Comparative immunogenicity of recombinant influenza hemagglutinin (rHA) and trivalent inactivated vaccine (TIV) among persons ≥65 years old

被引：54

作者：

Keitel, W. A. ^{[1
]}

Treanor, J. J. ^{[2
]}

El Sahly, H. M. ^{[1
]}

Gilbert, A. ^{[3
]}

Meyer, A. L. ^{[4
]}

Patriarca, P. A. ^{[5
]}

Cox, M. M. ^{[6
]}

机构：

[1] Baylor Coll Med, Houston, TX 77030 USA

[2] Univ Rochester, Rochester, NY USA

[3] Ockham Dev Grp Inc, Cary, NC USA

[4] Childrens Hosp, Med Ctr, Cincinnati, OH 45229 USA

[5] Biol Consulting Grp, Alexandria, VA USA

[6] Prot Sci Corp, Meriden, CT USA

来源：

VACCINE | 2009年 / 28卷 / 02期

关键词：

influenza vaccines; Recombinant hemagglutinin; Immunization; Immune responses; Comparative immunogenicity; PANDEMIC INFLUENZA; HOSPITALIZATIONS; REDUCTION; MORTALITY; PNEUMONIA; EFFICACY; SAFETY;

D O I：

10.1016/j.vaccine.2009.10.037

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Alternative substrates for influenza vaccine production are needed to ensure adequate supplies. We evaluated the relative safety and immunogenicity of recombinant hemagglutinin (rHA) or trivalent inactivated vaccine (TIV) among 869 >= 65-year-old subjects in a randomized clinical trial. Virologic surveillance for influenza-like illness (ILI) was conducted during the 2006-2007 epidemic. Vaccines were well tolerated. Seroconversion rates vs. influenza A/H1N1 and H3N2 antigens were superior in the rHA group, but were inferior vs. influenza B; however, results for influenza B are confounded since the vaccine antigens were different. ILI frequencies were low and similar in both groups. Studies assessing relative immunogenicity of vaccines using identical B Ags are warranted. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：379 / 385

页数：7

共 19 条

[1]

INFLUENZA VACCINATION OF ELDERLY PERSONS - REDUCTION IN PNEUMONIA AND INFLUENZA HOSPITALIZATIONS AND DEATHS [J].