Stereoselection in designed three-helix bundle metalloproteins

被引：27

作者：

Case, MA

Ghadiri, MR

Mutz, MW

McLendon, GL

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

[4] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

CHIRALITY | 1998年 / 10卷 / 1-2期

关键词：

de novo design; self-assembly; metalloproteins; diastereoselection;

D O I：

10.1002/chir.7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The stereochemical consequences of the metal-ion assisted self-assembly of parallel three-helix peptide bundles are investigated. Chiral induction in the self-assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange-inert metalloprotein provide structural insights into analogous exchange-labile systems. (C) 1998 Wiley-Liss, Inc.

引用

页码：35 / 40

页数：6

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