Histone H1 regulates chromatin condensation in Leishmania parasites

被引：13

作者：

Masina, Slavica ^{[1
]}

Zangger, Haroun ^{[1
]}

Rivier, Denis ^{[1
]}

Fasel, Nicolas ^{[1
]}

机构：

[1] Univ Lausanne, Dept Biochem, CH-1066 Epalinges, Switzerland

来源：

EXPERIMENTAL PARASITOLOGY | 2007年 / 116卷 / 01期

关键词：

MNase; MH1; LH1; HMG;

D O I：

10.1016/j.exppara.2006.11.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

We investigated the functional role of the Leishmania histone H1 and demonstrate for the first time that addition of histone H1 has a strong effect on microccocal digestion, chromatin condensation of parasite nuclei and that its overexpression can modulate parasite infectivity in vivo. (C) 2006 Elsevier Inc. All rights reserved.

引用

页码：83 / 87

页数：5

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