Parkinson's disease: A neurodegenerative disease particularly amenable to gene therapy

被引：17

作者：

Bohn, MC ^{[1
]}

机构：

[1] Northwestern Univ, Sch Med, Childrens Mem Inst Educ & Res, Chicago, IL 60614 USA

来源：

MOLECULAR THERAPY | 2000年 / 1卷 / 06期

关键词：

D O I：

10.1006/mthe.2000.0078

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：494 / 496

页数：3

共 11 条

[1] Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease [J].

BilangBleuel, A ;

Revah, F ;

Colin, P ;

Locquet, I ;

Robert, JJ ;

Mallet, J ;

Horellou, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (16) :8818-8823

[2]

Bohn MC, 1998, GENE THERAPY NEUROLO, P377

[3] Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor [J].

Choi-Lundberg, DL ;

Lin, Q ;

Schallert, T ;

Crippens, D ;

Davidson, BL ;

Chang, YN ;

Chiang, YWL ;

Qian, JA ;

Bardwaj, L ;

Bohn, MC .

EXPERIMENTAL NEUROLOGY, 1998, 154 (02) :261-275

[4] Dopaminergic neurons protected from degeneration by GDNF gene therapy [J].

ChoiLundberg, DL ;

Lin, Q ;

Chang, YN ;

Chiang, YL ;

Hay, CM ;

Mohajeri, H ;

Davidson, BL ;

Bohn, MC .

SCIENCE, 1997, 275 (5301) :838-841

[5] Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat [J].

Connor, B ;

Kozlowski, DA ;

Schallert, T ;

Tillerson, JL ;

Davidson, BL ;

Bohn, MC .

GENE THERAPY, 1999, 6 (12) :1936-1951

[6] CONDITIONED MEDIA DERIVED FROM GLIAL-CELL LINES PROMOTE SURVIVAL AND DIFFERENTIATION OF DOPAMINERGIC-NEURONS INVITRO - ROLE OF MESENCEPHALIC GLIA [J].

ENGELE, J ;

SCHUBERT, D ;

BOHN, MC .

JOURNAL OF NEUROSCIENCE RESEARCH, 1991, 30 (02) :359-371

[7]

Kordower JH, 1999, ANN NEUROL, V46, P419, DOI 10.1002/1531-8249(199909)46:3<419::AID-ANA21>3.0.CO

[8]

2-Q

[9]

KOZLOWSKI DA, 2000, IN PRESS EXP NEUROL

[10] GDNF - A GLIAL-CELL LINE DERIVED NEUROTROPHIC FACTOR FOR MIDBRAIN DOPAMINERGIC-NEURONS [J].

LIN, LFH ;

DOHERTY, DH ;

LILE, JD ;

BEKTESH, S ;

COLLINS, F .

SCIENCE, 1993, 260 (5111) :1130-1132

← 1 2 →