Protein carbonylation in human diseases

被引：756

作者：

Dalle-Donne, I

Giustarini, D

Colombo, R

Rossi, R

Milzani, A

机构：

[1] Univ Milan, Dept Biol, I-20133 Milan, Italy

[2] Univ Siena, Dept Neurosci, I-53100 Siena, Italy

来源：

TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 04期

关键词：

D O I：

10.1016/S1471-4914(03)00031-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxidative modifications of enzymes and structural proteins play a significant role in the aetiology and/or progression of several human diseases. Protein carbonyl content is the most general and well-used biomarker of severe oxidative protein damage. Human diseases associated with protein carbonylation include Alzheimer's disease, chronic lung disease, chronic renal failure, diabetes and sepsis. Rapid recent progress in the identification of carbonylated proteins should provide new diagnostic (possibly pre-symptomatic) biomarkers for oxidative damage, and yield basic information to aid the establishment an efficacious antioxidant therapy.

引用

收藏

页码：169 / 176

页数：8

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